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BPDEtide

Substrate for PKG and PKA
 
BML-P112-0001 1 mg 113.00 USD
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Replaces Prod. #: ALX-152-022

Sequence derived from bovine lung cGMP specific phosphodiesterase (cG-BPDE). Specific substrate for PKG, Km=68 µM; Km for PKA=320 µM, with no phosphorylation detected for CaMKII or PKC.

Product Specification

Alternative Name:cGMP-dependent protein kinase (PKG) substrate
 
Sequence:H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
 
Formula:C68H115N23O20
 
MW:1574.8
 
Source:Synthetic.
 
Formulation:Lyophilized.
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 

Product Literature References

A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases: J.L. Colbran, et al.; J. Biol. Chem. 267, 9589 (1992), Abstract; Full Text
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase: J.D Corbin & S.O. Døskeland; J. Biol. Chem. 258, 11391 (1983), Abstract; Full Text

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PKG
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