This sequence, ADAQHATPPKKKRKVED, is SV40 L Tag (118-138) with Ser to Ala120 and Ala123 substitutions to increase specificity. Substrate is specific for p34cdc2 (CDK1) and is a poor substrate for CKI, II, PKA, GSK3, PKC, CaMKII, and phosphorylase b kinase. Can be used in cell lysates using TCA/phosphocellulose assay. Km=74 µM for active complex with cyclin B.
Product Details
| Sequence: | Ala-Asp-Ala-Gln-His-Ala-Thr-Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-Pro-Lys-Asp-Phe |
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| MW: | 2406.7 |
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| CAS: | 135546-44-0 |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance: I. Pezzini, et al.; Nanomedicine (Lond.)
12, 403 (2017),
Abstract;
