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Ketanserin . tartrate

Serotonin receptor ligand
 
BML-NS515-0050 50 mg 115.00 USD
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Replaces Prod. #: ALX-550-051

Selective serotonin 5-HT2/5-HT1C  receptor antagonist.

Product Specification

Formula:C22H22FN3O3 . C4H6O6
 
MW:545.5
 
CAS:83846-83-7
 
Purity:≥99%
 
Appearance:White solid.
 
Solubility:Soluble in DMSO, 100% ethanol (3mg/ml) or water (4mg/ml)
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from moisture.
 
BML-NS515 structure
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BML-NS515 structure

Product Literature References

Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes: K. Naito, et al.; Biol. Pharm. Bull. 39, 570 (2016), Application(s): Effects of Various Doses of Selective 5-HT2 Receptor Antagonists on DNA Synthesis and Proliferation in Hepatocytes, Abstract; Full Text
Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes: K. Naito, et al.; Biol. Pharm. Bull. 39, 121 (2016), Application(s): Antagonist for 5-HT2, Abstract; Full Text
Differences in the effects of ketanserin and GR127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein: Z. Razzaque, et al.; Eur. J. Pharmacol. 283, 199 (1995), Abstract;
Ketanserin and ritanserin discriminate between recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes: J.M. Zgombick, et al.; Eur. J. Pharmacol. 291, 9 (1995), Abstract;
[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role: J.E. Leysen, et al.; Mol. Pharmacol. 21, 301 (1982), Abstract;
The pharmacology of ketanserin, the first selective serotonin S2-antagonist: F. Awouters, et al.; Drug Dev. Res. 6, 263 (1981), Abstract;
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors: J.M. Van Nueten, et al.; J. Pharmacol. Exp. Ther. 218, 217 (1981), Abstract;

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