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Bupropion . HCl

Inhibitor of dopamine and norepinephrine transporters
 
BML-NS111-0050 50 mg 70.00 USD
 
BML-NS111-0250 250 mg 296.00 USD
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Inhibits dopamine and norepinephrine transporters (Ki=2.8 and 1.4µM respectively). Inhibits the serotonin transporter at higher concentration (Ki=45µM). In clinical use as an antidepressant and for smoking cessation. Also acts as a nicotinic receptor antagonist.

Product Specification

Formula:C13H18ClNO . HCl
 
MW:276.2
 
CAS:31677-93-7
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in water (>25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-NS111 structure
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BML-NS111 structure

Product Literature References

l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats: S.L. Faison, et al.; BMC Pharmacol. Toxicol. 17, 49 (2016), Abstract;
Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies: G.I. Papakostas, et al.; J. Clin. Psychiatry 69, 1287 (2008), Abstract;
Treating tobacco dependence: state of the science and new directions: C. Lerman, et al.; J. Clin. Oncol. 23, 311 (2005), Abstract;
Bupropion is a nicotinic antagonist: J.E. Slemmer, et al.; J. Pharmacol. Exp. Ther. 295, 321 (2000), Abstract; Full Text
Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo: B.R. Cooper, et al.; J. Pharmacol. Exp. Ther. 215, 127 (1980), Abstract;

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