Inhibits dopamine and norepinephrine transporters (Ki=2.8 and 1.4µM respectively). Inhibits the serotonin transporter at higher concentration (Ki=45µM). In clinical use as an antidepressant and for smoking cessation. Also acts as a nicotinic receptor antagonist.
Product Details
| Formula: | C13H18ClNO . HCl |
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| MW: | 276.2 |
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| CAS: | 31677-93-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (>25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats: S.L. Faison, et al.; BMC Pharmacol. Toxicol.
17, 49 (2016),
Abstract;
Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies: G.I. Papakostas, et al.; J. Clin. Psychiatry
69, 1287 (2008),
Abstract;
Treating tobacco dependence: state of the science and new directions: C. Lerman, et al.; J. Clin. Oncol.
23, 311 (2005),
Abstract;
Bupropion is a nicotinic antagonist: J.E. Slemmer, et al.; J. Pharmacol. Exp. Ther.
295, 321 (2000),
Abstract;
Full Text
Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo: B.R. Cooper, et al.; J. Pharmacol. Exp. Ther.
215, 127 (1980),
Abstract;
