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N-Desmethyl Clozapine

Serotonin receptor ligand
 
BML-NS106-0005 5 mg 88.00 USD
 
BML-NS106-0025 25 mg 363.00 USD
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Major metabolite of clozapine. Potent serotonin 5-HT1c receptor antagonist.

Product Specification

Alternative Name:Norclozapine
 
Formula:C17H17ClN4
 
MW:312.8
 
CAS:6104-71-8
 
Purity:≥99% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in ethanol (25 mg/ml) or DMSO (>44 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-NS106 structure
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BML-NS106 structure

Product Literature References

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract; Full Text
Metabolism and bioactivation of clozapine by human liver in vitro: M. Pirmohamed, et al.; J. Pharmacol. Exp. Ther. 272, 984 (1995), Abstract;
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther. 268, 1403 (1994), Abstract;
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993), Abstract;
On-line fully automated determination of clozapine and desmethylclozapine in human serum by solid-phase extraction on exchangeable cartridges and liquid chromatography using a methanol buffer mobile phase on unmodified silica: O.V. Olesen & B. Poulsen; J. Chromatog. 622, 39 (1993), Abstract;

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