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Clozapine N-oxide

Major metabolite of clozapine
 
BML-NS105-0005 5 mg 83.00 USD
 
BML-NS105-0025 25 mg 365.00 USD
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  • High Purity
  • Active in vitro and in vivo
  • Possesses little or no activity at 5-HT receptors.
Major metabolite of clozapine. Possesses little or no activity at 5-HT receptors.

Product Specification

Formula:C18H19ClN4O . CH3OH
 
MW:342.8 . 32.0
 
CAS:34233-69-7
 
Formulation:Contains 1 equivalent of methanol.
 
Purity:≥99% (HPLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in water (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20°C for up to 4 months.
 
Scientific Background:Clozapine is an antipsychotic medication used in the treatment of schizophrenia, and is also sometimes used off-label for the treatment of bipolar disorder and borderline personality disorder. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
 
BML-NS105 structure
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BML-NS105 structure

Product Literature References

An Inhibitory Septum to Lateral Hypothalamus Circuit That Suppresses Feeding: P. Sweeney & Y. Yang; J. Neurosci. 36, 11185 (2016), Abstract;
Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion: S. Koehler, et al.; Sci. Rep. 6, 35400 (2016), Application(s): Western blot, Immortalized mouse podocytes; Mouse injections, Abstract; Full Text
The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation: A. Inutsuka, et al.; Sci. Rep. 6, 29480 (2016), Application(s): Drugs and pharmacogenetic drug administration, Abstract; Full Text
Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures: F. Yi, et al.; Epilepsia 56, 297 (2015), Abstract;
Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease: I.S. Pienaar, et al.; Mol. Neurodegener. 10, 47 (2015), Application(s): In vivo, Abstract; Full Text
Activation and inhibition of transient receptor potential TRPM3-induced gene transcription: A. Lesch, et al. ; Br. J. Pharmacol. 171, 2645 (2014), Abstract;
Chemogenetic silencing of neurons in retrosplenial cortex disrupts sensory preconditioning: S. Robinson, et al.; J. Neurosci. 34, 10982 (2014), Abstract;
CREB Regulates Memory Allocation in the Insular Cortex: Y. Sano, et al.; Curr. Biol. 24, 2833 (2014), Abstract;
Cyclin-Dependent Kinase 5 in the Ventral Tegmental Area Regulates Depression-Related Behaviors: P. Zhong, et al.; J. Neurosci. 34, 6352 (2014), Abstract; Full Text
Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition: F. Yi, et al.; J. Physiol. 592, 3463 (2014), Abstract;
Regulation of immediate-early gene transcription following activation of Gα(q)-coupled designer receptors: A. Kaufmann, et al.; J. Cell. Biochem. 114, 681 (2013), Abstract;
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL): E. Alvarez-Curto, et al.; Mol. Pharmacol. 80, 1033 (2011), Abstract; Full Text
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract; Full Text
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther. 268, 1403 (1994), Abstract;
Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites: G. Lin, etal.; J. Pharm. Sci. 83, 1412 (1994), Abstract;

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