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Blocking peptide for Neurokinin-1 receptor pAb (Prod. No. BML-NA4200)

 
BML-NP1442-0100 100 µg 74.00 USD
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This peptide was used to generate the guinea pig polyclonal antiserum to neurokinin-1 receptor (BML-NA4200). The peptide was synthesized using the Fmoc-polyamide mode of solid-phase synthesis. The peptide is suitable for use in negative control (antibody blocking) experiments in Western blotting and immunohistochemistry. The sequence exhibits a single amino acid substitution in the aligned sequence of mouse NK1R (M405I), two changes in the guinea pig NK1R sequence (M395V; A407S) and four changes in the human sequence (S399F; Y402S; M405V; A407S).

Product Specification

Sequence:Lys-Thr-Met-Thr-Glu-Ser-Ser-Ser-Phe-Tyr-Ser-Asn-Met-Leu-Ala
 
MW:1696.9
 
Purity:≥95% (HPLC)
 
Appearance:White powder.
 
Solubility:Soluble in water and aqueous buffers.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor: T.M. Fong, et al.; Mol. Pharmacol. 41, 24 (1992), Abstract;
Human substance P receptor (NK-1): Organization of the gene, chromosome localization, and functional expression of cDNA clones: N.P. Gerard, et al.; Biochemistry 30, 10640 (1991), Abstract;
Molecular cloning, structural characterization and functional expression of the human substance P receptor: Y. Takeda, et al.; Biochem. Biophys. Res. Commun. 179, 1232 (1991), Abstract;
Organization, structure, and expression of the gene encoding the rat substance P receptor: A.D. Hershey, et al.; J. Biol. Chem. 266, 4366 (1991), Abstract;
Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain: C.R. Gerfen, et al.; Brain Res. 556, 165 (1991), Abstract;
Molecular characterization of a functional cDNA encoding the rat substance P receptor: A.D. Hershey & J.E. Krause; Science 247, 958 (1990), Abstract;
Substance P receptors in the nervous system and possible receptor subtypes: L.L. Iversen, et al.; CIBA Found. Symp. 186-205 (1982), Abstract;

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