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Resiniferatoxin

PKC activator, TRPV1 agonist
 
BML-NK100-0001 1 mg 131.00 USD
 
BML-NK100-0005 5 mg 495.00 USD
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Replaces Prod. #: ALX-550-179

Ultrapotent capsaicin analog which stimulates protein kinase C (PKC). Induces release of Substance P from afferent nociceptive specific neurons. Potent agonist of TRPV1. Potent neurotoxin.

Product Specification

Alternative Name:RTX
 
Formula:C37H40O9
 
MW:628.7
 
Source:Isolated from Euphorbia poisonii.
 
CAS:57444-62-9
 
RTECS:CY1633700
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White amorphous solid.
 
Solubility:Soluble in 100% ethanol or DMSO; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
BML-NK100 structure
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BML-NK100 structure

Product Literature References

Memory of pain: the effect of perineural resiniferatoxin: I. Kissin, et al.; Anesth. Analg. 103, 721 (2006), Abstract;
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin: M. Raisinghani, et al.; J. Physiol. 567, 771 (2005), Abstract;
Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells: M.R. Frey, et al.; Biochem. Pharmacol. 67, 1873 (2004), Abstract;
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain: M.Z. Chou, et al.; Biochemistry 43, 2501 (2004), Abstract;
Conformational studies on resiniferatoxin (RTX), an ultrapotent vanilloid agonist: S.F. Victory, et al.; Bioorg. Med. Chem. 6, 223 (1998), Abstract;
Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine: G. Appendino & A. Szallasi; Life Sci. 60, 681 (1997), (Minireview), Abstract;
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol. 107, 544 (1992), Abstract;
Release of calcitonin gene-related peptide from sensory neurons: J.M. Lundberg, et al.; Ann. NY Acad. Sci. 657, 187 (1992), Abstract;
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor: A. Szallasi & P.M. Blumberg; Life Sci. 47, 1399 (1990), Abstract;
Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons: J. Szolcsanyi, et al.; J. Pharmacol. Exp. Ther. 255, 923 (1990), Abstract;
Sensory neuron-specific actions of capsaicin: mechanisms and applications: S. Bevan & J. Szolcsányi; TIPS 11, 330 (1990), Abstract;
Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes: A. Szallasi & P.M. Blumberg; Brain Res. 524, 106 (1990), Abstract;
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper: A. Szallasi & P.M. Blumberg; Neuroscience 30, 515 (1989), Abstract;
On the active principles of the spurge family (Euphorbiaceae). V. Extremely skin-irritant and moderately tumor-promoting diterpene esters from Euphorbia resinifera Berg: M. Hergenhahn, et al.; J. Cancer Res. Clin. Oncol. 108, 98 (1984), Abstract;
Structure-activity relations of polyfunctional diterpenes of the daphnane type. I. Revised structure for resiniferatoxin and structure-activity relations of resiniferonol and some of its esters: W. Adolf, et al.; J. Nat. Prod. 45, 347 (1982), Abstract;

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