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Azelastine . HCl

Histamine H1 receptor antagonist
 
BML-NH108-0100 100 mg 72.00 USD
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A unique Histamine H1 receptor antagonist displaying broad spectrum anti-allergic and anti-inflammatory activity. It inhibits production of IL-6, TNF-&alpha and IL-8 as well as NF-κB activation in human mast cells. In guinea pigs it inhibits leukotriene production and leukotriene-mediated acute lung anaphylaxis.

Product Specification

Formula:C22H24CIN3O . HCL
 
MW:418.4
 
CAS:79307-93-0
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-NH108 structure
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BML-NH108 structure

Product Literature References

Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells: D. Kempuraj, et al.; Int. Arch. Allergy Immunol. 132, 231 (2003), Abstract;
Azelastine nasal spray: a review of pharmacology and clinical efficacy in allergic and nonallergic rhinitis: P.L. Lieberman & R.A. Settipane; Allergy Asthma Proc. 24, 95 (2003), Abstract;
Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs: N. Chand, et al.; Allergy 41, 473 (1986), Abstract;

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