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R(-)-α-Methylhistamine . 2HBr

Histamine receptor ligand
 
BML-NH104-0010 10 mg 177.00 USD
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Replaces Prod. #: ALX-550-130

Potent and selective histamine H3 agonist. Crosses the blood-brain barrier and inhibits histamine synthesis and release at nanomolar concentrations.

Product Specification

Formula:C6H11N3 . 2HBr
 
MW:287.0
 
CAS:868698-49-1
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Very hygroscopic.
 
BML-NH104 structure
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BML-NH104 structure

Product Literature References

Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective ligands: R.W. Hew, et al.; Br. J. Pharmacol. 101, 621 (1990), Abstract;
Distribution, properties, and functional characteristics of three classes of histamine receptor: S.J. Hill; Pharmacol. Rev. 42, 45 (1990), Abstract;
Plenary lecture. A third histamine receptor subtype: characterisation, localisation and functions of the H3-receptor: J.C. Schwartz, et al.; Agents Actions 30, 13 (1990), Abstract;
Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain: R. Oishi, et al.; J. Neurochem. 52, 1388 (1989), Abstract;
Highly potent and selective ligands for histamine H3-receptors: J.M. Arrang, et al.; Nature 327, 117 (1987), Abstract;

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