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Neuron specific enolase monoclonal antibody (47)

 
BML-NA1501-0100 100 µl 108.00 USD
 
BML-NA1501-0500 500 µl 334.00 USD
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Product Specification

Alternative Name:NSE, γ, γ'-enolase, Enolase 2, ENO2
 
Clone:NSE47
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Neuron-specific enolase extracted from cow brain.
 
UniProt ID:P09104 (human)
 
Species reactivity:Mammalian
 
Specificity:Recognizes NSE in a wide range of mammalian species.
 
Applications:ELISA, IHC, WB
 
Application Notes:Detects a band of ~76kDa by Western blot.
 
Purity Detail:Partially purified.
 
Formulation:Liquid. In PBS containing 0.01M sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase) is composed of two subunits and exists in three molecular forms in human brain: non-neuronal enolase (NNE; α,α’-enolase), neuron-specific enolase (NSE; γ,γ’-enolase, also known as 14-3-2 protein and NSP) and the short-lived heterodimer α,γ’-enolase. The neuron-specific form is a highly acidic homodimeric protein of 78kDa which has been found in central and peripheral nervous elements and also in many neuroendocrine cells and derivative tumours. NSE is regarded as the best described serum marker for small cell lung cancer (SCLC). In addition, the measurement of NSE levels in both serum and cerebrospinal fluid following cerebral ischaemia and traumatic head injury provides a reliable laboratory indicator of the degree of brain cell damage and may allow early prediction of prognostic outcome.
 

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