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Tetracaine . HCl

Na+ channel blocker
 
BML-NA144-0005 5 g 33.00 USD
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Local anesthetic that can be used topically or for spinal anesthesia. Potent inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8.

Product Specification

Alternative Name:4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester . HCl
 
Formula:C15H24N2O2 . HCl
 
MW:264.3 . 36.5
 
CAS:136-47-0
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (>25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at - 20°C for up to 3 months.
 
BML-NA144 structure
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BML-NA144 structure

Product Literature References

Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: conventional and automated patch clamp analysis: A. Randall, et al.; Pharmacol. Res. 54, 118 (2006), Abstract;
Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23: V.H. John, et al.; Neuropharmacology 46, 425 (2004), Abstract;
Evaluation of a novel topical anesthetic agent for cutaneous laser resurfacing: a randomized comparison study: T.S. Alster & J.R. Lupton; Dermatol. Surg. 28, 1004 (2002), Abstract;
Pain and rehabilitation after spinal cord injury: the case of sensory spasticity?: B.H. Sjolund; Brain Res. Brain Res. Rev. 40, 250 (2002), Abstract;

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