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A-803467

Na+ channel blocker
 
BML-NA142-0010 10 mg 86.00 USD
 
BML-NA142-0050 50 mg 367.00 USD
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A-803467 is a potent and selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8 which is preferentially expressed on sensory neurons. IC50 for human Nav1.8=8.0 nM (140 nM for rat). It attenuates neuropathic and inflammatory pain in various animal models.

Product Specification

Formula:C19H16ClNO4
 
MW:357.8
 
Source:Synthetic.
 
CAS:944261-79-4
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (15mg/ml) or 100% ethanol (2mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-NA142 structure
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BML-NA142 structure

Product Literature References

A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats: S. McGaraughty, et al.; J. Pharmacol. Exp. Ther. 324, 1204 (2008), Abstract; Full Text
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat: M.F. Jarvis, et al.; Proc. Natl. Acad. Sci. USA 104, 8520 (2007), Abstract; Full Text

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