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Batrachotoxin

Na+ channel activator
 
BML-NA141-0010 10 µg 262.00 USD
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Batrachotoxin is a potent neurotoxin and cardiotoxin found in the skin of various poisonous frogs. BTX binds specifically to voltage-gated Na+ channels causing steady state activation, preventing all forms of inactivation, slowing deactivation and altering ion selectivity.
Use extreme caution! May cause death.

Product Specification

Alternative Name:BTX
 
Formula:C31H42N2O6
 
MW:538.7
 
CAS:23509-16-2
 
Purity:≥90% (HPLC, TLC, Toxicity)
 
Appearance:Thin film.
 
Solubility:Soluble in DMSO, methanol or 100% ethanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-NA141 structure
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BML-NA141 structure

Product Literature References

How batrachotoxin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis: S. Y. Wang, et al.; Mol. Pharmacol. 69, 788 (2006), Abstract; Full Text
Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation: N. B. Cronin, et al.; J. Biol. Chem. 278, 10675 (2003), Abstract; Full Text

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