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PD-85639

Na+ channel blocker
 
BML-NA140-0025 25 mg Inquire for pricing
 
BML-NA140-0005 5 mg Inquire for pricing
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PD-85839 is a potent and selective sodium channel blocker. It binds specifically to a local anesthetic receptor site on the Na+ channel alpha subunit that is allosterically linked to neurotoxin receptor site 21. PD-85639 is a novel and useful molecular probe of this important drug receptor site.

Product Specification

Formula:C24H32N2O
 
MW:364.5
 
CAS:150034-24-5
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (5mg/ml) or ethanol (4mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-NA140 structure
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BML-NA140 structure

Product Literature References

Sodium and potassium channel modulators: their role in neuroprotection: T. P. Obrenovitch, et al.; Int. Rev. Neurobiol. 40, 109 (1997), Abstract;
Inhibition of Na+ channels by the novel blocker PD85,639: D. S. Ragsdale, et al.; Mol. Pharmacol. 43, 949 (1993), Abstract;
Specific binding of the novel Na+ channel blocker PD85,639 to the alpha subunit of rat brain Na+ channels: W. Thomsen, et al.; Mol Pharmacol. 43, 955 (1993), Abstract;

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