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Kavain (+/-)

Na+ channel blocker
 
BML-NA136-0050 50 mg 68.00 USD
 
BML-NA136-0250 250 mg 278.00 USD
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Kavain is one constituent of kava-kava, an herbal drug of the South Pacific islands, which displays anti-convulsive, anxiolytic, analgesic and muscle relaxing properties. Kavain inhibits voltage-dependent Na+ channels in rat CA1 hippocampal neurons. It displays protective effects in the MPTP mouse model of Parkinson's disease but potentiates NMDA toxicity in the developing hippocampus.

Product Specification

Alternative Name:(±)-4-Methoxy-6-styryl-5,6-dihydro-α-pyrone
 
Formula:C14H14O3
 
MW:230.3
 
CAS:500-64-1
 
Purity:≥98%
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-NA136 structure
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BML-NA136 structure

Product Literature References

Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus: P. J. Mulholland, et al.; Brain Res. 945, 106 (2002), Abstract;
Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease: N. Schmidt, et al.; Synapse 40, 47 (2001), Abstract;
Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons: E. I. Magura, et al.; Neuroscience 81, 345 (1997), Abstract;

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