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QX-314

Na+ channel blocker
 
BML-NA134-0100 100 mg 70.00 USD
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Replaces Prod. #: ALX-550-252

Quaternary derivative of lidocaine (Prod. No. ALX-550-251). Blocks voltage-gated Na+ channels. Effectively blocks cardiac Na+ channels when applied from either side of the membrane but blocks neuronal Na+channels only from the intracellular side. Externally applied QX-314 was shown to inhibit high frequency activity in sensory nerves

Product Specification

Formula:C16H27BrN2O
 
MW:343.3
 
CAS:21306-56-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in water or DMSO.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
550-252
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550-252

Product Literature References

QX-314 Induces Analgesia to Nociceptive Thermal Stimulus by Co-Application with Capsiate or Anandamide: H. Nakagawa, et al.; Austin Biomark. Diagn. 1, 1 (2014), Application(s): Injection, Full Text
Local anesthetic block of batrachotoxin-resistant muscle Na+ channels: G.K. Wang, et al.; Mol. Pharmacol. 54, 389 (1998), Abstract;
QX-314 inhibits ectopic nerve activity associated with neuropathic pain: I. Omana-Zapata, et al.; Brain Res. 771, 228 (1997), Abstract;
Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel: Y. Qu, et al.; PNAS 92, 11839 (1995), Abstract;
Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gating: J.Z. Yeh & G.S. Oxford; J. Gen. Physiol. 85, 603 (1985), Abstract;
Effects of local anesthetic QX-314 on the membrane properties of hippocampal pyramidal neurons: B.W. Connors & D.A. Prince; J. Pharmacol. Exp. Ther. 220, 476 (1982), Abstract;

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