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Tetrodotoxin

Na+ channel blocker
 
BML-NA120-0001 1 mg 225.00 USD
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Replaces Prod. #: ALX-630-002

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Tetrodotoxin is a non-peptide toxin isolated from ovaries and liver of Chinese puffer fish. Neurotoxin. Potent and reversible inhibitor of the voltage dependent Na+ channels in nerve membranes.

Product Specification

Alternative Name:TTX, Fugu poison
 
Formula:C11H17N3O8
 
MW:319.3
 
CAS:4368-28-9
 
MI:14: 9246
 
RTECS:IO1450000
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in dilute acetic acid (e.g. 1mg/ml in 10mM HOAc or 10mg/ml in 0.1M HOAc) or in citric acid/sodium citrate buffer, pH 4.8 (e.g. 1mg/ml in 20mM buffer). Do not use alkaline solution.
 
Shipping:Ambient
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Avoid strongly acidic or alkaline solutions. USE EXTREME CAUTION! MAY CAUSE DEATH.
 
630-002
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630-002

Product Literature References

Tetrodotoxin poisoning: D.F. Hwang & T. Noguchi; Adv. Food Nutr. Res. 52, 141 (2007), Abstract;
Recent advances in the study of mechanism of action of marine neurotoxins: T. Narahashi, et al.; Neurotoxicology 15, 545 (1994), Abstract;
Functional properties of rat brain sodium channels expressed in a somatic cell line: T. Scheuer, et al.; Science 247, 854 (1990), Abstract;
Structure and function of voltage-sensitive ion channels: W.A. Catterall; Science 242, 50 (1988), Abstract;
Molecular properties of voltage-sensitive sodium channels: W.A. Catterall; Annu. Rev. Biochem. 55, 953 (1986), Abstract;
Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes: W.A. Catterall; Annu. Rev. Pharmacol. Toxicol. 20, 15 (1980), Abstract;
The constituents of the ovaries of globefish. VIII. Studies on tetrodotoxin: K. Tsuda & M. Kawamura; Pharm. Bull. 1, 112 (1953), Abstract;

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