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U-69593

Opioid receptor ligand
 
BML-N705-0005 5 mg 97.00 USD
 
BML-N705-0025 25 mg 404.00 USD
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Replaces Prod. #: ALX-550-060

Selective κ-opioid agonist. Thought to be selective for the κ-1 subtype (KD=3.8nM in human cerebral cortex membranes). Immunomodulatory activity.

Product Specification

Formula:C22H32N2O2
 
MW:356.5
 
Source:Synthetic.
 
CAS:96744-75-1
 
Purity:≥99% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol, 0.1N hydrogen chloride, or DMSO. Insoluble in water or 0.1N sodium hydroxide.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
550-060
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550-060

Product Literature References

Ligand binding profiles of U-69, 593-sensitive and-insensitive sites in human cerebral cortex membranes: evidence of kappa opioid receptors heterogeneity: K.W. Kim et al.; Life Sci. 58, 1671 (1996), Abstract;
Immunomodulatory activity of mu- and kappa-selective opioid agonists: D.D. Taub et al.; PNAS 88, 360 (1991), Abstract;
Kappa-opioid receptors and analgesia: M.J. Millan; Trends Pharmacol. Sci. 11, 70 (1990), Abstract;
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes: R.B. Rothman et al.; Eur. J. Pharmacol. 167, 345 (1989), Abstract;

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