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Gambogic amide

TrkA ligand
 
BML-N159-0001 1 mg 97.00 USD
 
BML-N159-0005 5 mg 347.00 USD
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A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM (see reference S.-W. Jang, et al. 2007).

Product Specification

Formula:C38H45NO7
 
MW:627.8
 
CAS:286935-60-2
 
Purity:≥98% (TLC)
 
Appearance:Yellow-orange solid.
 
MeltingPoint:74-76°C
 
Solubility:Soluble in DMSO (20mg/ml) or ethanol (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death: S.-W. Jang, et al.; Proc. Natl. Acad. Sci. USA 104, 16329 (2007), Abstract; Full Text

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