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Clioquinol

Metalloproteinase activator
 
BML-N158-0005 5 g 111.00 USD
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A metal chelating ligand which displays protective effects in various neurodegenerative states. It has shown to modulate amyloid β-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12 it totally rescues lead-induced impairments of synaptic plasticity in an animal model.

Product Specification

Alternative Name:5-Chloro-7-iodo-8-quinolinol
 
Formula:C9H5INOCl
 
MW:305.5
 
CAS:130-26-7
 
Purity:≥97% (Assay)
 
Appearance:Tan solid.
 
Solubility:Soluble in DMSO (>25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Clioquinol and vitamin B12 (cobalamin) synergistically rescue the lead-induced impairments of synaptic plasticity in hippocampal dentate gyrus area of the anesthetized rats in vivo: W. H. Chen, et al.; Neuroscience 147, 853 (2007), Abstract;
Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands: A. Caragounis, et al.; Biochem. J. 407, 435 (2007), Abstract; Full Text
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity: A. R. White, et al.; J. Biol. Chem. 281, 17670 (2006), Abstract; Full Text
Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model: T. Nguyen, et al.; Proc. Natl. Acad. Sci. USA 102, 11840 (2005), Abstract; Full Text

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