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SEW-2871

S1P receptor ligand
 
BML-LP106-0050 50 mg 223.00 USD
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SEW-2871 is a novel, potent EDG receptor agonist structurally unrelated to sphingosine-1-phosphate and is highly selective for the human S1P1 receptor. It inhibits lymphocyte recirculation in vivo and produces immunosuppression without associated bradycardia which is induced by other less selective S1P agonists. In mice SEW-2871 blocked TNFα induced monocyte adhesion to endothelium.

Product Specification

Alternative Name:5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
 
Formula:C20H10F6N2OS
 
MW:440.4
 
CAS:256414-75-2
 
Purity:≥98%
 
Appearance:White solid.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.: C. C. Yeh, et al.; Am. J. Physiol. Heart Circ. Physiol. 296, H1193 (2009), Application(s): In vivo assays in mice, Abstract; Full Text
The Sphingosine 1-Phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo: A.M. Wolf, et al.; J. Immunol. 183, 3751 (2009), Abstract;
S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.: Y. H. Lien, et al.; Kidney Int. 69, 1601 (2006), Application(s): In vivo assays in mice, Abstract; Full Text
Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.: D. T. Bolick, et al.; Arterioscler. Thromb. Vasc. Biol. 25, 976 (2005), Application(s): In vivo assays in mice, Abstract; Full Text
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.: M. G. Sanna, et al.; J. Biol. Chem. 279, 13839 (2004), Application(s): Calcium flux, kinase, cell migration and in vivo assays in mice, spleen cells, primary lymphocytes and CHO cells, Abstract; Full Text

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