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Phosphatidic acid, dipalmitoyl

PKC activator
 
BML-LP103-0100 100 mg 106.00 USD
 
BML-LP103-0500 500 mg 422.00 USD
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Replaces Prod. #: ALX-300-045

A mitogenic lipid phosphate produced via the action of phospholipase D. Mediates agonist-dependent Raf-1 translocation and activation of the MAP kinase cascade.

Product Specification

Alternative Name:1,2-Dipalmitoyl-sn-glycero-3-phosphate . sodium salt, DPPA
 
Formula:C35H68O8P·Na
 
MW:670.9
 
CAS:169051-60-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Fine suspension in ethanol (5mg/ml) with 15 minutes of sonication at room temperature.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras: M.A. Rizzo, et al.; J. Biol. Chem. 275, 23911 (2000), Abstract;
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway: M.A. Rizzo, et al.; J. Biol. Chem. 274, 1131 (1999), Abstract;
A role for phospholipase D in control of mitogenesis: M.R. Boarder; Trends Pharmacol. Sci. 15, 57 (1994), Abstract;

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