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Leukotriene E4

Prostanoid receptor ligand
 
BML-LE004-0050 50 µg 219.00 USD
 
BML-LE004-1000 1 mg 2,795.00 USD
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Less potent than LTD4 in smooth muscle contractile activity and mucus secretion in airways. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension and airway hyperresponsiveness. Partial agonist at LTD4 receptors. LTE4 solely activates a CysLT1 receptor. Biosynthesis from LTD4 by a dipeptidase.

Product Specification

Alternative Name:LTE4
 
Formula:C23H37NO5S
 
MW:439.6
 
CAS:75715-89-8
 
Concentration:50 µg/ml
 
Formulation:Solution in methanol/ammonium acetate buffer, 70:30, pH 5.6.
 
Purity:≥98% (HPLC)
 
Appearance:Liquid.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Store, as supplied, at -80°C for up to 1 year.
 
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Product Literature References

Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma: K. Sakata & M. Back ; Eur. J. Pharmacol. 436, 119 (2002), Abstract;
Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma: J.P. Arm, et al.; Am. Rev. Resp. Dis. 140, 148 (1989), Abstract;
Mechanisms of leukotriene E4 partial agonist activity at leukotriene D4 receptors in differentiated U-937 cells: D.L. Saussy, et al.; J. Biol. Chem. 264, 19845 (1989), Abstract; Full Text
Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4: S.-E. Dahlen, et al.; Proc. Natl. Acad. Sci. USA 80, 1712 (1983), Abstract; Full Text
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro: Z. Marom, et al.; Am. Rev. Resp. Dis. 126, 449 (1982), Abstract;
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response: S.-E. Dahlen, et al.; Proc. Natl. Acad. Sci. USA 78, 3887 (1981), Abstract; Full Text
Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro: J.M. Drazen, et al.; Proc. Natl. Acad. Sci. USA 77, 4354 (1980), Abstract; Full Text

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