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Leukotriene C4

Prostanoid receptor ligand
 
BML-LC004-0050 50 µg 268.00 USD
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Replaces Prod. #: ALX-340-043

A cysteinyl leukotriene which acts as potent agonist for contraction of smooth muscle. Induces microvascular permeability and mucus secretion in airways. Enhances growth of human airway epithelial cells. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension. Stimulates angiogenesis. Stimulates LH8, LHRH9 and prolactin release. Produced in specific cell types or by transcellular biosynthesis and rapidly metabolized to LTD4 and LTE4. Transported by the multidrug resistance protein (MRP; Km=35nM).

Product Specification

Alternative Name:LTC4, 5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
 
Formula:C30H47N3O9S
 
MW:625.8
 
Source:Synthetic.
 
CAS:72025-60-6
 
MI:14: 5455
 
Concentration:50µg/ml
 
Purity:≥95% (HPLC)
 
Appearance:Colorless solution.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -80°C. Protect from exposure to air. Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of stock solutions may be evaporated to near dryness under a stream of nitrogen and dissolved in ethanol. Stock solutions may be used directly for HPLC analysis.
 
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Product Literature References

ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter: S. Paul et al.; Proc. Natl. Acad. Sci. USA 93, 6929 (1996), Abstract;
Cysteinyl leukotrienes in asthma: old mediators up to new tricks: D.W. Hay et al.; Trends Pharmacol. Sci. 16, 304 (1995), Abstract;
Leukotriene C4 receptors on guinea pig tracheocytes: S. Prie et al.; J. Pharmacol. Exp. Ther. 274, 312 (1995), Abstract;
Leukotrienes and inflammation: S.D. Brain & T.J. Williams; Pharmacol. Ther. 46, 57 (1990), Abstract;
Transcellular biosynthesis of eicosanoids: J. Maclouf et al.; Pharmacol. Res. 21, 1 (1989), Abstract;
Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes: S.J. Feinmark & P.J. Cannon; J. Biol. Chem. 261, 16466 (1986), Abstract;
Leukotrienes as mediators of ischemia and shock: A.M. Lefer; Biochem. Pharmacol. 35, 123 (1986), Abstract;
Metabolism of leukotrienes: S. Hammarstrom et al.; Mol. Cell Biochem. 69, 7 (1985), Abstract;
Leukotrienes and the cardiovascular system: G. Feuerstein; Prostaglandins 27, 781 (1984), Abstract;

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