Leukotriene C4

Prostanoid receptor ligand



BML-LC004-0050	50 µg	382.00 USD
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Replaces Prod. #: ALX-340-043

A cysteinyl leukotriene which acts as potent agonist for contraction of smooth muscle. Induces microvascular permeability and mucus secretion in airways. Enhances growth of human airway epithelial cells. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension. Stimulates angiogenesis. Stimulates LH8, LHRH9 and prolactin release. Produced in specific cell types or by transcellular biosynthesis and rapidly metabolized to LTD4 and LTE4. Transported by the multidrug resistance protein (MRP; K_m=35nM).

Product Details

Alternative Name:	LTC₄, 5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

Formula:	C₃₀H₄₇N₃O₉S

MW:	625.8

Source:	Synthetic.

CAS:	72025-60-6

MI:	14: 5455

Concentration:	50µg/ml

Formulation:	Liquid. In methanol/ammonium acetate buffer, 65:35 pH=5.6.

Purity:	≥95% (HPLC)

Appearance:	Colorless solution.

Shipping:	Dry Ice

Long Term Storage:	-80°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at -80°C. Protect from exposure to air. Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of stock solutions may be evaporated to near dryness under a stream of nitrogen and dissolved in ethanol. Stock solutions may be used directly for HPLC analysis.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter: S. Paul et al.; Proc. Natl. Acad. Sci. USA 93, 6929 (1996), Abstract;

Cysteinyl leukotrienes in asthma: old mediators up to new tricks: D.W. Hay et al.; Trends Pharmacol. Sci. 16, 304 (1995), Abstract;

Leukotriene C4 receptors on guinea pig tracheocytes: S. Prie et al.; J. Pharmacol. Exp. Ther. 274, 312 (1995), Abstract;

Leukotrienes and inflammation: S.D. Brain & T.J. Williams; Pharmacol. Ther. 46, 57 (1990), Abstract;

Transcellular biosynthesis of eicosanoids: J. Maclouf et al.; Pharmacol. Res. 21, 1 (1989), Abstract;

Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes: S.J. Feinmark & P.J. Cannon; J. Biol. Chem. 261, 16466 (1986), Abstract;

Leukotrienes as mediators of ischemia and shock: A.M. Lefer; Biochem. Pharmacol. 35, 123 (1986), Abstract;

Metabolism of leukotrienes: S. Hammarstrom et al.; Mol. Cell Biochem. 69, 7 (1985), Abstract;

Leukotrienes and the cardiovascular system: G. Feuerstein; Prostaglandins 27, 781 (1984), Abstract;