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Ginkgolide B

PAF receptor ligand
 
BML-L135-0010 10 mg 60.00 USD
 
BML-L135-0050 50 mg 224.00 USD
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Most potent member of the ginkgolide family of PAF antagonists. Ginkgolide B accelerates PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Inhibits PAF-induced PMNL chemotaxis (IC50=490 nM). Orally effective against PAF-induced bronchospasm.

Product Specification

Alternative Name:BN 52021
 
Formula:C20H24O10
 
MW:424.4
 
CAS:15291-77-7
 
Purity:≥90% (HPLC)
 
Appearance:White crystalline powder.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit: F. Bonin, et al.; J. Biol. Chem. 279, 52425 (2004), Abstract; Full Text
Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells: S. G. Ward, et al.; Br. J. Pharmacol. 93, 769 (1988), Abstract; Full Text
Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage: G. M. Vercelloti, et al.; Blood 71, 1100 (1988), Abstract; Full Text
Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects: N. Tamura, et al.; Biochem. Biophys. Res. Commun. 142, 638 (1987), Abstract;
Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig: S. Desquand, et al.; Eur. J. Pharmacol. 127, 83 (1986), Abstract;
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988: D. Nunez, et al.; Eur. J. Pharmacol. 123, 197 (1986), Abstract;

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