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Octylonium bromide

PAF receptor inhibitor
 
BML-L131-0005 5 mg 77.00 USD
 
BML-L131-0025 25 mg 303.00 USD
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Binds to rabbit platelet PAF receptors with high affinity. Inhibits PAF-induced platelet aggregation in rabbits (IC50=7.7 µM), bronchoconstriction in guinea-pigs, hypotension in rats and lethality in mice. Inhibits endotoxin-induced gastrointestinal damage (known to be due to PAF). Does not inhibit PAF-induced contraction of guinea pig lung parenchymal strips. Clinically useful spasmolytic agent for the control of increased tone or motility of the gut.

Product Specification

Alternative Name:Otilonium bromide
 
Formula:C29H43N2O4Br
 
MW:563.6
 
CAS:26095-59-0
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (12 mg/ml), DMSO (>25 mg/ml) or ethanol (>25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Octylonium bromide, an antagonist of platelet-activating factor: A. Subissi, et al.; Arch. Int. Pharmacodyn. 302, 255 (1989), Abstract;
Further studies on the pharmacodynamic properties and organ selectivity of octylonium bromide: S. Manzini, et al.; Drugs Exp. Clin. Res. 14, 265 (1988), Abstract;

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