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bis(Methylthio)gliotoxin

PAF receptor ligand
 
BML-L122-0001 1 mg 145.00 USD
 
BML-L122-0005 5 mg 395.00 USD
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Inhibits PAF-induced platelet aggregation (IC50=8.4 µM) and collagen-induced aggregation (IC50=84.2 µM) with no effect on arachidonic acid or ADP induced aggregation. Inhibits PAF-induced bronchoconstriction in vivo in the guinea-pig (69% at 1.0 mg/kg).

Product Specification

Alternative Name:FR-49175
 
Formula:C15H20N2O4S2
 
MW:356.5
 
CAS:74149-38-5
 
Purity:≥99% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml) and ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months.
 
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Product Literature References

NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro: C. Ward, et al.; J. Biol. Chem. 274, 4309 (1999), Abstract;
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB: H.L. Pahl, et al.; J. Exp. Med. 183, 1829 (1996), Abstract;
Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives: M. Okamoto, et al.; Chem. Pharm. Bull. (Tokyo) 34, 340 (1986), Abstract;
Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models: M. Okamoto, et al.; Chem. Pharm. Bull. (Tokyo) 34, 345 (1986), Abstract;

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