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NS-1643

K+ channel activator
 
BML-KC169-0010 10 mg 95.00 USD
 
BML-KC169-0050 50 mg 385.00 USD
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A novel and selective HERG K+ channel activator (EC50=10.5 µM). Activates ERG2 channels. Displays antiarrhythmic properties in rabbit models.

Product Specification

Alternative Name:N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl] urea
 
Formula:C15H10F6N2O3
 
MW:380.2
 
CAS:448895-37-2
 
Purity:≥98% (TLC)
 
Appearance:White solid
 
Solubility:Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome: T.G. Diness, et al.; Cardiovasc. Res. 79, 61 (2008), Abstract;
Activation of ERG2 potassium channels by the diphenylurea NS1643: P. Elmedyb, et al.; Neuropharmacology 53, 283 (2007), Abstract;
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643): R.S. Hansen, et al.; Mol. Pharmacol. 69, 266 (2006), Abstract;

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