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α-Dendrotoxin

K+ channel blocker
 
BML-KC167-0140 140 µg 495.00 USD
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α-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom, by modification of the procedures of Harvey and Benishin and purified to homogeneity. α-Dendrotoxin blocks Kv1.1 and Kv1.2 channels (IC50= 0.4 to 4 and 1.1 to 12 nM in oocytes respectively, with higher values for mammalian cells). In addition, the toxin was shown to block also Kv1.6 (IC50= 9-25 nM).

Product Specification

Sequence:Gln-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly
 
MW:7048.1
 
CAS:74504-53-3
 
Purity:≥98% (HPLC)
 
Appearance:Lyophilized solid.
 
Solubility:Soluble in any aqueous buffer. Please centrifuge all product preparations at 10000 x g for 5 minutes before reconstitution.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

General Literature References

Dendrotoxin poisoning in a neurobiochemist: S.W. Munday, et al.; J. Toxicol. Clin. Toxicol. 41, 163 (2003), Abstract;

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