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TRAM-34

K+ channel blocker
 
BML-KC161-0005 5 mg 100.00 USD
 
BML-KC161-0025 25 mg 394.00 USD
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TRAM-34 is a potent and selective inhibitor of the intermediate-conductance Ca2+-activated potassium channel (IKCa). It displays immunosuppressive activity and inhibits the proliferation of endometrial cancer cells.

Product Specification

Alternative Name:1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
 
Formula:C22H17ClN2
 
MW:344.8
 
CAS:289905-88-0
 
Purity:≥98% (HPLC)
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in DMSO (10 mg/mL at 40°C) or ethanol (6 mg/mL at 40°C).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-KC161 structure
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BML-KC161 structure

Product Literature References

Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer: Z. H. Wang, et al.; Oncogene 26, 5107 (2007), Abstract;
K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression: G. Panyi, et al.; Curr. Pharm. Des. 12, 2199 (2006), Abstract;
K+ channels as targets for specific immunomodulation: K. G. Chandy, et al.; Trends Pharmacol. Sci. 25, 280 (2004), Abstract; Full Text
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant: H. Wulff, et al.; Proc. Natl. Acad. Sci. USA 97, 8151 (2000), Abstract; Full Text

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