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Penitrem A

K+ channel blocker
 
BML-KC157-0001 1 mg 56.00 USD
 
BML-KC157-0005 5 mg 156.00 USD
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Replaces Prod. #: ALX-630-020

Fungal mycotoxin. Selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ (maxi-K) channel (100% block at 10 nM). Increases spontaneous release of GABA and aspartate from cerebrocortical synaptosomes in rat neuromuscular junction.

Product Specification

Alternative Name:NSC 354845, Tremortin A
 
Formula:C37H44ClNO6
 
MW:634.2
 
CAS:12627-35-9
 
RTECS:RY7535000
 
Purity:≥95% (HPLC, TLC)
 
Appearance:White solid.
 
Solubility:Soluble in organic solvents such as methanol, acetone or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light.
 
BML-KC157 structure
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BML-KC157 structure

Product Literature References

Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study: P. Breton, et al.; Toxicon 36, 645 (1998), Abstract;
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry 33, 5819 (1994), Abstract;
Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations: B.J. Wilson, et al.; Brain Res. 40, 540 (1972), Abstract;

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