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Paxilline

K+ channel blocker
 
BML-KC155-0005 5 mg 99.00 USD
 
BML-KC155-0025 25 mg 441.00 USD
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Replaces Prod. #: ALX-630-019

Paxilline is an indole alkaloid isolated from Penicillium paxilli. It is a selective and reversible blocker of the smooth muscle high conductance Ca2+-activated K+ (maxi-K) channel (70% block at 10 nM). In neutrophils, Paxilline blockage of BKCa channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. Inhibitor of the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor. 

Product Specification

Formula:C27H33NO4
 
MW:435.6
 
CAS:57186-25-1
 
RTECS:DJ2830000
 
Purity:≥97% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light.
 
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Product Literature References

The mycotoxin paxilline inhibits the cerebellar inositol 1,4, 5-trisphosphate receptor: C.L. Longland, et al.; Eur. J. Pharmacol. 408, 219 (2000), Abstract;
Effects of channel modulators on cloned large-conductance calcium-activated potassium channels: V.K. Gribkoff, et al.; Mol. Pharmacol. 50, 206 (1996), Abstract;
Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel: M. Sanchez & O.B. McManus; Neuropharmacology 35, 963 (1996), Abstract;
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry 33, 5819 (1994), Abstract;
Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel: J. Vazquez, et al.; J. Biol. Chem. 265, 15564 (1990), Abstract;
A new tremorgenic metabolite from Penicillium paxilli: R.J. Cole, et al.; Can. J. Microbiol. 20, 1159 (1974), Abstract;

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