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Nicorandil

K+ channel activator
 
BML-KC152-0050 50 mg 50.00 USD
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Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. It attenuates MMP-2 and -9 plasma levels, thereby suppressing ventricular remodeling. A clinically useful antianginal agent.

Product Specification

MW:211.2
 
CAS:65141-46-0
 
Purity:≥98% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
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Product Literature References

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons: M.M. Georgiadis, et al.; DNA Repair (Amst.) 41, 32 (2016), Application(s): Cell culture, Abstract;
Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction: T. Fujiwara, et al.; Heart Vessels 22, 303 (2007), Abstract;
Nicorandil improves post-ischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts: C. Lu, et al.; Circ. J. 70, 1650 (2006), Abstract;
Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction: S. Horinaka, et. al.; Cardiovasc. Drugs Ther. 18, 13 (2004), Abstract;
SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil: T. Shindo, et al.; Br. J. Pharmacol. 124, 985 (1998), Abstract;

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