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Valinomycin

Potassium ionophore
 
BML-KC140-0025 25 mg 78.00 USD
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Replaces Prod. #: ALX-450-012

A potassium ionophore. Induces mitochondrial swelling. Induces apoptosis in CHO cells and other cell lines. Antagonizes endothelin-induced vasoconstriction (IC50=0.3µM).

Product Specification

Formula:C54H90N6O18
 
MW:1111.3
 
Source:Isolated from Streptomyces fulvissimus
 
CAS:2001-95-8
 
Purity:≥97% (TLC), ≥92% (HPLC)
 
Appearance:White crystalline solid.
 
Solubility:Soluble in 100% ethanol (50mg/ml), acetic acid, chloroform, DMSO or ether.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Cyclosporin A does not protect the disruption of the inner mitochondrial membrane potential induced by potassium ionophores in intact K562 cells: L.F. Marques-Santos, et al.; Cell Biol. Int. 30, 197 (2006), Abstract;
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78: I.-J. Ryoo, et al.; Biol. Pharm. Bull. 29, 817 (2006), Abstract;
Valinomycin-induced apoptosis in Chinese hamster ovary cells: R. Abdalah, et al.; Neurosci. Lett. 405, 68 (2006), Abstract;
Valinomycin-induced apoptosis of human NK cells is predominantly caspase independent: A. Paananen, et al.; Toxicology 212, 37 (2005), Abstract;
Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification: I.J. Furlong, et al.; Cell Death Differ. 5, 214 (1998), Abstract;
Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential: Y. Inai, et al.; Cell. Struct. Funct. 22, 555 (1997), Abstract;
Combination of the electrogenic ionophores, valinomycin and CCCP, can lead to non-electrogenic K+/H+ exchange on bilayer lipid membranes: V.N. Orlov, et al.; FEBS Lett. 345, 104 (1994), Abstract;
K+ ionophores inhibit nerve growth factor-induced neuronal differentiation in rat adrenal pheochromocytoma PC12 cells: H. Harada, et al.; Biochim. Biophys. Acta 1220, 310 (1994), Abstract;
The effect of respiration on the permeability of the mitochondrial membrane to ions: S. Luvisetto, et al.; Biochim. Biophys. Acta 1186, 12 (1994), Abstract;
Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry: C.L. Deckers, et al.; Exp. Cell. Res. 208, 362 (1993), Abstract;
Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction: S. Kim, et al.; Biochem. Biophys. Res. Commun. 164, 1003 (1989), Abstract;
Valinomycin-based K+ selective microelectrodes with low electrical membrane resistance: D. Ammann, et al.; Neurosci. Lett. 74, 221 (1987), Abstract;
Opposing interactions of ionophores (valinomycin and monensin) on calcium ion uptake in rat retinal preparations: J.B. Lombardini; Neurochem. Res. 10, 77 (1985), Abstract;
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), Abstract;

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