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PCO 400

K+ channel activator
 
BML-KC131-0020 20 mg 53.00 USD
 
BML-KC131-0100 100 mg 213.00 USD
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PCO 400 is an analog of cromakalim (KATP) channels. It is a potent and selective opener of ATP-sensitive K+ (KATP) channels.

Product Specification

Alternative Name:(-)-(3S,4R)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(3-oxocyclopent-1-enyl-1-oxy)-2H-1-benzpyran-6-carbonitrile
 
Formula:C17H17NO4
 
MW:299.3
 
CAS:121055-10-5
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid
 
MeltingPoint:154-156°C
 
Solubility:Soluble in ethanol (30 mg/ml) and DMSO (>200 mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months
 
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Product Literature References

Analysis of the relaxant action of SDZ PCO 400 in airway smooth muscle from the ox and guinea-pig: R. C. Small, et al.; Eur. J. Pharmacol. 219, 81 (1992), Abstract;
Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways: I. D. Chapman, et al.; Br. J. Pharmacol. 106, 423 (1992), Abstract; Full Text

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