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Minoxidil sulfate

K+ channel activator
 
BML-KC130-0005 5 mg 88.00 USD
 
BML-KC130-0025 25 mg 308.00 USD
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Replaces Prod. #: ALX-550-259

A selective ATP-sensitive K+ (KATP) channel opener. It is the active metabolite of minoxidil (Prod. No. BML-KC125) and is a potent (IC50=0.14 µM) vascular smooth muscle relaxant. Antihypertensive. Stimulates renin secretion.

Product Specification

Alternative Name:U-58838
 
Formula:C9H15N5O4S
 
MW:289.3
 
CAS:83701-22-8
 
Purity:≥98%
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Make solution fresh before use.
 
Technical Info/Product Notes:Minoxidil sulfate will slowly convert to minoxidil in DMSO solutions.
 
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Product Literature References

Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells: Y. Nakaya, et al.; J. Dermatol. Sci. 7, S104 (1994), Abstract;
A specific binding site for K+ channel openers in rat aorta: K.M. Bray & U. Quast; J. Biol. Chem. 267, 11689 (1992), Abstract;
Clinical pharmacology of potassium channel openers: K.E. Andersson; Pharmacol. Toxicol. 70, 244 (1992), Abstract;
K+ channel openers and insulin release: P. Lebrun, et al.; Life Sci. 51, 795 (1992), Abstract;
R.C. Gadwood & V.C. Fiedler; Ann. Rep. Med. Chem. 24, 187 (1989),
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle: R.J. Winquist, et al.; J. Pharmacol. Exp. Ther. 248, 149 (1989), Abstract;
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability: K.D. Meisheri, et al.; J. Pharmacol. Exp. Ther. 245, 751 (1988), Abstract;

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