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Minoxidil

K+ channel activator
 
BML-KC125-0100 100 mg 67.00 USD
 
BML-KC125-0500 500 mg 297.00 USD
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Replaces Prod. #: ALX-550-258

A selective ATP-sensitive K+ (KATP) channel opener. It is metabolized to the more active sulfate in vivo. A clinically useful anti-alopecia. Antihypertensive. Stimulates renin secretion. Potent vascular smooth muscle relaxant.

Product Specification

Alternative Name:U-10858
 
Formula:C9H15N5O
 
MW:209.3
 
CAS:38304-91-5
 
MI:14: 6203
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol (29mg/ml), DMSO (6.5mg/ml) or water (2.2mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Possible presence of the ATP-sensitive K+ channel in isolated spinal dorsal horn neurons of the rat: S. Yamashita, et al.; Neurosci. Lett. 170, 208 (1994), Abstract;
Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil: K.D. Meisheri, et al.; Biochem. Pharmacol. 45, 271 (1993), Abstract;
Potassium channel conductance as a control mechanism in hair follicles: A.E. Buhl, et al.; J. Invest. Dermatol. 101, 148S (1993), Abstract;
Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts: T. Hautala, et al.; Biochem. J. 283, 51 (1992), Abstract;
R.C. Gadwood & V.C. Fiedler; Annu. Rep. Med. Chem. 24, 187 (1988),
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability: K.D. Meisheri, et al.; J. Pharmacol. Exp. Ther. 245, 751 (1988), Abstract;
Minoxidil: a review of its pharmacological properties and therapeutic use: V.M. Campese; Drugs 22, 257 (1981), Abstract;

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