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5-Ketoeicosa-6E,8Z,11Z,14E-tetraenoic acid

R527 ligand
BML-K005-0050 50 µg 186.00 USD
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Stimulates neutrophil degranulation and Ca2+ mobilization by a mechanism independent of the LTB4 receptor. Has been shown to act as an agonist at a G protein-coupled receptor (R527). Induces the infiltration of granulocytes into human skin.

Product Specification

Concentration:50 µg/ml
Formulation:Oil dissolved in ethanol
Purity:≥95% (HPLC)
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:Store, as supplied, at -80°C for up to 1 year.
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Product Literature References

5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin: S. Muro, et al.; J. Allergy Clin. Immunol. 112, 768 (2003), Abstract;
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils: C.E. Jones, et al.; Mol. Pharmacol. 63, 471 (2003), Abstract; Full Text
5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration: W.S. Powell, et al.; J. Immunol. 154, 4123 (1995), Abstract;
5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements: U. Schwenk & J.M. Schroeder ; J. Biol. Chem. 270, 15029 (1995), Abstract;
Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils: W.S. Powell, et al.; J. Lipid Res. 36, 2590 (1995), Abstract; Full Text
5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus: J.T. O'Flaherty, et al.; Biochem. Biophys. Res. Commun. 192, 129 (1993), Abstract;

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