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Mycophenolate mofetil

Immunosuppressant
 
BML-IM101-0020 20 mg 67.00 USD
 
BML-IM101-0100 100 mg 202.00 USD
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Mycophenolate mofetil (CellCept) is an immunosuppressant prodrug of mycophenolic acid, a fermentation product of Penicillium brevicompactum. Immunosuppression occurs via inhibition of type II inosine-5’-monophosphate dehydrogenase, depleting guanosine preferentially in T and B lymphocytes. In addition, mycophenolic acid displays anti-inflammatory activity by preventing NO production specifically from iNOS and by blocking glycosylation and expression of adhesion molecules and therefore recruitment of lymphocytes and monocytes to sites of inflammation.

Product Specification

Formula:C23H31NO7
 
MW:433.5
 
Source:Isolated from Penicillium brevicompactum.
 
CAS:128794-94-5
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml, warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Solutions can be stored for up to 3 months at -20°C.
 
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Product Literature References

Mycophenolate mofetil and its mechanisms of action: A.C. Allison & E.M. Euqui; Immunopharmacology 47, 85 (2000), Abstract;
Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells: M. Senda, et al.; Transplantation 60, 1143 (1995), Abstract;
Mycophenolic acid and brequinar, inhibitors of purine and pyrimidine synthesis, block the glycosylation of adhesion molecules: A.C. Allison, et al.; Transplant. Proc. 25, 67 (1993), Abstract;
In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443: A.C. Allison, et al.; Transplant. Proc. 23, 10 (1991), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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