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12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE)

Thromboxane synthase inhibitor
 
BML-HP012-0050 50 µg 275.00 USD
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Replaces Prod. #: ALX-340-057

Primary metabolite of arachidonic acid via the 12-lipoxygenase pathway. Inhibits thromboxane synthase. Inhibits platelet aggregation via activation of guanylate cyclase (100% at 5µM). Stimulates leukotriene biosynthesis. Potent and selective inhibitor of Ca2+-calmodulin-dependent protein kinase II (IC50=0.7µM). Endogenous TRPV1 agonist (Ki=0.35µM).

Product Specification

Alternative Name:12(S)-HPETE
 
Formula:C20H32O4
 
MW:336.5
 
CAS:71774-10-2
 
Concentration:50µg/ml
 
Formulation:Solution in ethanol.
 
Purity:≥98%
 
Appearance:Liquid.
 
Solubility:Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes.For experiments with cells or tissues, aliquots of ethanol solutions may be added
 
Handling:After opening, prepare aliquots and store at -80°C.
 
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Product Literature References

Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia: J. Shin, et al.; PNAS 99, 10150 (2002), Abstract;
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances: S.W. Hwang, et al.; PNAS 97, 6155 (2000), Abstract;
12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol. 39, 671 (1991), Abstract;
Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites: D. Piomelli, et al.; PNAS 86, 8550 (1989), Abstract;
Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid: J. Maclouf, et al.; PNAS 79, 6042 (1982), Abstract;
Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets: S. Hammarstrom & P. Falardeau; PNAS 74, 3691 (1977), Abstract;

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