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13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

Inhibits thromboxane production in human platelets
 
BML-HO013-0050 50 µg 75.00 USD
 
BML-HO013-1000 1 mg 802.00 USD
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Biosynthesis in rabbit peritoneal serous membranes, atherosclerotic plaques, healthy blood vessels, psoriatic skin, endothelial cells. Stimulates prostacyclin production by endothelial cells. Inhibits thromboxane production in human platelets. Inhibits platelet and tumor cell adhesion to endothelium. Antagonizes 12-HETE-induced tumor cell adhesion to endothelium. Stimulates DNA synthesis in BALB/c 3T3 fibroblasts.

Product Specification

Alternative Name:13(S)-HODE
 
Formula:C18H32O3
 
MW:296.5
 
Source:Synthetic.
 
CAS:29623-28-7
 
Concentration:50 µg/ml
 
Formulation:Solution in ethanol.
 
Purity:≥99% (HPLC)
 
Appearance:Clear to light-yellow liquid.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
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Product Literature References

Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity: T. A. Haas, et al.; Biochim. Biophys. Acta 1051, 174 (1990), Abstract;
Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts: W.C. Glasgow & T.E. Eling ; Mol. Pharmacol. 38, 503 (1990), Abstract;
Regulation of tumor cell adhesion by intracellular 13-HODE: 15-HETE ratio: E. Bastida, et al.; J. Lipid Mediators 2, 281 (1990), Abstract;
Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid: I.M. Grossi, et al.; Cancer Res. 49, 1029 (1989), Abstract; Full Text
13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets: B.N.Y. Setty, et al.; Biochem. Biophys. Res. Commun. 148, 528 (1987), Abstract;
13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells: B.N.Y. Setty, et al.; Biochem. Biophys. Res. Commun. 146, 502 (1987), Abstract;
13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX: M.R. Buchanan, et al.; J. Biol. Chem. 260, 16056 (1985), Abstract; Full Text

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