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8(S)-Hydroxyeicosa-5Z,9E,11Z,14Z-tetraenoic acid (HETE)

Activator of PKC and PPARα
 
BML-H008-0050 50 µg 251.00 USD
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Replaces Prod. #: ALX-340-037

Biosynthesis in human neutrophils, phorbol ester-treated mouse epidermis and by hepatic microsomal cytochrome P-450. Chemotactic for neutrophils. Activator of PPARα. Activates mouse skin protein kinase C (PKC).

Product Specification

Alternative Name:8(S)-HETE
 
Formula:C20H32O3
 
MW:320.5
 
CAS:98462-03-4
 
Concentration:50μg/ml
 
Formulation:Liquid. In ethanol.
 
Purity:≥99% (HPLC)
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -80°C.
 
Technical Info/Product Notes:Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. For HPLC, aliquots of ethanol solutions should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration.
 
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Product Literature References

Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans: Y. Guan, et al.; Am. J. Physiol. 273, F1013 (1997), Abstract;
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu, et al.; J. Biol. Chem. 270, 23975 (1995), Abstract;
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites: H.H. Lo, et al.; Lipids 29, 547 (1994), Abstract;
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin: M.A, Hughes & A.R. Brash; Biochim. Biophys. Acta 1081, 347 (1991), Abstract;

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