BML-281

HDAC6 inhibitor



BML-GR361-0001	1 mg	77.00 USD

BML-GR361-0005	5 mg	309.00 USD

Selective HDAC6 inhibitor (IC₅₀=0.002nM). IC₅₀values for other HDACs are 271, 252, 0.42, 6851 and 90.7 nM for HDACs 1,2,3,8 and 10 respectively. Potent inhibitor of the proliferation of a variety of pancreatic cancer cell lines (IC₅₀s in the 0.1-0.6µM range).

Product Specification

Alternative Name:	N-Hydroxy-7-[5-(4-tertbutoxycarbonylaminophenyl)-3-isoxazolecarboxamido]heptanamide

Formula:	C₂₂H₃₀N₄O₆

MW:	446.5

Purity:	≥98% (TLC)

Appearance:	Off-white solid.

CAS:	1045792-66-2

Solubility:	Soluble in DMSO (15 mg/ml).

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to 3 months.

Please mouse over

Product Literature References

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6 : A.P. Kozikowski, et al.; J. Med. Chem. 51, 4370 (2008), Abstract; Full Text