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BML-281

HDAC6 inhibitor
 
BML-GR361-0001 1 mg 90.00 USD
 
BML-GR361-0005 5 mg 350.00 USD
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Selective HDAC6 inhibitor (IC50=0.002nM). IC50 values for other HDACs are 271, 252, 0.42, 6851 and 90.7 nM for HDACs 1,2,3,8 and 10 respectively. Potent inhibitor of the proliferation of a variety of pancreatic cancer cell lines (IC50s in the 0.1-0.6µM range).

Product Specification

Alternative Name:N-Hydroxy-7-[5-(4-tertbutoxycarbonylaminophenyl)-3-isoxazolecarboxamido]heptanamide
 
Formula:C22H30N4O6
 
MW:446.5
 
CAS:1045792-66-2
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (15 mg/ml).
 
Shipping:Ambient
 
Short Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to one year.  Store solutions at -20°C for up to 3 months.
 
BML-GR361
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BML-GR361

Product Literature References

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6 : A.P. Kozikowski, et al.; J. Med. Chem. 51, 4370 (2008), Abstract; Full Text

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