BML-278

SIRT activator



BML-GR359-0005	5 mg	67.00 USD

BML-GR359-0025	25 mg	268.00 USD

Novel Sirt activator structurally based on a dihydropyridine scaffold. EC₁₅₀ (effective concentration able to increase enzyme activity by 150%) =1μM for Sirt1 with weaker effect on Sirt2 and Sirt3 (25 and 50μM respectively). The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells.

Product Specification

Alternative Name:	N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine

Formula:	C₂₄H₂₅NO₄

MW:	391.5

Purity:	≥98% (TLC)

Appearance:	Off-white solid.

Solubility:	Soluble in DMSO (5mg/ml).

Long Term Storage:	Ambient

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors: A. Mai, et al.; J. Med. Chem. 52, 5496 (2009), Abstract;