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BML-278

SIRT activator
 
BML-GR359-0005 5 mg 78.00 USD
 
BML-GR359-0025 25 mg 312.00 USD
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Novel Sirt activator structurally based on a dihydropyridine scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) =1μM for Sirt1 with weaker effect on Sirt2 and Sirt3 (25 and 50μM respectively). The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells.

Product Specification

Alternative Name:N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
 
Formula:C24H25NO4
 
MW:391.5
 
Source:Synthetic.
 
CAS: 15301-69-6
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
BML-GR359
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BML-GR359

Product Literature References

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors: A. Mai, et al.; J. Med. Chem. 52, 5496 (2009), Abstract;

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