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Mirin

MRN inhibitor
 
BML-GR357-0005 5 mg 82.00 USD
 
BML-GR357-0025 25 mg 330.00 USD
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The MRN-ATM pathway is essential for sensing the signaling from DNA double-strand breaks. Mirin is an inhibitor of MRN discovered using a forward chemical genetic screen. It prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity and it inhibits Mre11-associated exonuclease activity. IC50=66μM. It abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells.

Product Specification

Alternative Name:Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
 
Formula:C10H8N2O2S
 
MW:220.3
 
Source:Synthetic.
 
CAS:299953-00-7
 
Purity:≥95% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml) or DMF (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
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Product Literature References

Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex: K.M. Garner, et al.; Nat. Chem. Biol. 5, 129 (2009), Abstract;
Reply to 'Corrected structure of mirin, a small-molecule inhibitor of the Mre11–Rad50–Nbs1 complex': S. Peterson, et al.; Nat. Chem. Biol. 5, 130 (2009), Abstract;
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex: A. Dupre, et al.; Nat. Chem. Biol. 4, 119 (2008), Abstract;

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