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ITSA-1

HDAC inhibitor
 
BML-GR350-0025 25 mg 86.00 USD
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Replaces Prod. #: ALX-270-382

ITSA-1 is a cell permeable benzotriazole amide that counteracts trichostatin A (Prod. No. BML-GR309) induced cell cycle arrest, histone acetylation and transcriptional activation but not the activity of other HDAC inhibitors.

Product Specification

Alternative Name:N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide
 
Formula:C13H7Cl2N3O
 
MW:292.1
 
CAS:200626-61-5
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light. Packaged under inert gas.
 
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Product Literature References

Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation: K.M. Koeller, et al.; Chem. Biol. 10, 397 (2003), Abstract;
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays: S.J. Haggarty, et al.; Chem. Biol. 10, 383 (2003), Abstract;

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