Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Chaetocin

Methyltransferase inhibitor
 
BML-GR349-0200 200 µg 88.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-380-242

Chaetocin, an antitumor antibiotic, is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.

Product Specification

Formula:C30H28N6O6S4
 
MW:696.9
 
Source:Isolated from Chaetomium sp.
 
CAS:28097-03-2
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml), dimethyl formamide or methanol. Poorly souble in water.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-GR349 structure
Please mouse over
BML-GR349 structure

Product Literature References

Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a: X. Zhang, et al.; Toxicol. Appl. Pharmacol. 304, 42 (2016), Application(s): Cell culture, Abstract;
The anticancer effect of chaetocin is enhanced by inhibition of autophagy: H. J. Jung, et al.; Cell Death Dis. 7, e2098 (2016), Application(s): Cell culture, Abstract;
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress: C.R. Isham, et al.; Blood 109, 2579 (2007), Abstract;
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9: D. Greiner, et al.; Nat. Chem. Biol. 1, 143 (2005), Abstract;
[Isolation and configuration of Chaetocin]: D. Hauser, et al.; Helv. Chim. Acta. 53, 1061 (1970), (Article in German), Abstract;

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Brochures
Stem Cells
Stem Cells
Download as PDF

Brochures
Epigenetics
Epigenetics
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,