Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. It induces apoptosis in HeLa cells (100µM) where it down regulates global gene expression. Acetylation of histone H4 by p300 was more sensitive to inhibition by garcinol compared with that of H3. Histone H4 acetylation was completely inhibited at 1 µM while acetylation of H3 was not abolished at 20 µM.
Product Details
Formula: | C38H50O6 |
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MW: | 602.8 |
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Source: | Synthetic. |
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CAS: | 78824-30-3 |
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Purity: | ≥95% (TLC) |
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Identity: | Determined by NMR. |
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Appearance: | Yellow solid. |
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Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml) or dimethylformamide (25mg/ml). |
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Shipping: | Blue Ice |
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Short Term Storage: | -20°C |
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Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Handling: | Protect from exposure to air |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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