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Tanshinone IIA

AP-1 inhibitor
 
BML-GR336-0005 5 mg 90.00 USD
 
BML-GR336-0025 25 mg 357.00 USD
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Tanshinone IIA is a diterpenoid naphthoquinone found in the traditional Chinese medicine Tanshen (Salvia sp). It inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50=0.22 µM) and induces apoptosis in a variety of cell lines

Product Specification

Formula:C19H18O3
 
MW:294.3
 
CAS:568-72-9
 
Purity:≥93% (HPLC)
 
Appearance:Orange solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
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Product Literature References

Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza: B.Y. Kang, et al.; Immunopharmacology 49, 355 (2000), Abstract;
S. Park, et al.; Bull. Korean Chem. Soc. 20, 925 (1999),
Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3: H.J. Sung, et al.; Exp. Mol. Med. 31, 174 (1999), Abstract;

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